ACTH-Z 及び合成 ACTH の抗原性に関する比較研究

概要

論文の詳細を見る
It has been controverisal that whether ACTH itself or contaminated substance are responsible for the adverse effects, especially in anaphylactic reaction of ACTH-Z. To make this point clear, the authors intended to compare the antigenicities of ACTH-Z and synthetic ACTH. Antigenicity of ACTH-Z was confirmed as follows: 1) positive skin reactions were observed over the half of the patients who had been treated with this drug, 2) anaphylactic reactions were seen in all sensitized guinea pigs with this drug, 3) anaphylactic contractions of the ileum occured in all guinea pigs sensitized with this substance (Schultz-Dale reaction). This reaction was potentiated markedly by simultaneous application of sodium succinate. However, any of these phenomenon was not seen in the cases sensitized with synthetic ACTH both in clinical and experimental studies. Furthermore, cross reaction between ACTH-Z and synthetic ACTH from either side was not seen in those three experimental studies. From these observations, it was suggested that contaminated foreign body in ACTH-Z may be responsible for anaphylactic reaction but not ACTH itself in the preparation, and ACTH-Z can be replaced by synthetic ACTH more safely in clinical uses.
日本アレルギー学会の論文
1969-10-30