モルモットの抗原抗体反応に特異的なコハク酸の促進効果
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概要
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The enhancing effect of sodium succinate on in vitro anaphylactic histamine release from guinea-pig lung has been reported. Succinate also enhanced evidently the anaphylactic contraction of guinea-pig ileum as well as the degranulation of mast cells in the mesentery produced by the rabbit anti-guinea pig serum in vitro. Further, a systemic injection of succinate aggravated the cutaneous edema elicited by the intracutaneous injection of anti-serum. These effects of succinate seem to be specific to the antigen-antibody reactions in guinea pigs since all these reactions in rats were not effected except that oxygen uptake in the rat lung tissue was increased as in the guinea pig. Similar reactions induced by compound 48/80 or histamine were not enhanced in guinea pigs. Alpha-ketoglutarate and malate among other intermediates of Krebs cycle, and glucose showed a slight increasing effect on the anaphylactic histamine release from guinea-pig lung, but not in oxygen uptake. Maleate which is not an energy-yielding substrate had and effect enhancing all these antigen-antibody reactions in guinea pigs, but not in rats, in similar fashion to succinate; however, maleate did not increase oxygen uptake. The anaphylactic histamine release and oxygen uptake were both inhibited by the metabolic inhibitors such as cyanide, 2, 4-dinitro-phenol and iodoacetate either in the presence or absence of succinate. Malonate was an effective inhibitor of all these antigen-antibody reactions which were enhanced by succinate and also by maleate. Succinate did not accelerate the desensitization. These observations provide some obstacles to accept the interpretation which attributes the succinate effect on the antigen-antibody reactions simply to ints energy-enharnessing metabolic effect on the basis of energy-requiring processes in anaphylactic histamine release. Succinate may act on the step after the union of antigen and antibody but not on the step being displayed by released chemical mediators.
- 一般社団法人日本アレルギー学会の論文
- 1969-09-30
著者
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遠藤 晃市
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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遠藤 晃市
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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遠藤 晃市
岡山大学医学部薬理学教室
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- モルモットの抗原抗体反応に特異的なコハク酸の促進効果