分子ポテンシャル理論に基づく骨格筋の収縮運動解析 : サルコメア単位の収縮運動特性

概要

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In this paper, the phenomenological potential theory, obtained by the modificaton of Mitsui's self-induced translation model, is applied to the simulation of the contraction of a sarcomere in skeletal muscle. The equation of motion of each myosin head is solved under the viscosity dominant assumption. The isotonic and isometric contractions of a half sarcomere was simulated. The numerical result of the load-velocity relationship at the isotonic contraction shows a good agreement with Hill's experimental equation. The numerical result of the length-tension relationship contents with Gordon's experimental result qualitatively. The result of quick release in the isometric contraction demonstrated the visco-elastic feature of skeletal muscle. Therefore, it can be concluded that this macromolecular dynamics simulation will contribute the investigation of the mechanism of skeletal muscle contraction.
1994-10-25