骨格筋の興奮収縮連関の実験と数値解析

概要

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The in vitro experiment of excitation-contraction coupling of semitendinousus muscle of Rana Castesbeiana has been done. We measured the time history of tension force in case of isotonic contraction. The characteristics of the force history changed according to the condition of electric pulse stimulation, e. g. , from twitch to tetanus for single and sequential stimulation, respectively. Two numerical models to analyze the complete E-C coupling dynamics are proposed. One is the modified self-induced translation model, the other is the biochemical reaction model, which is newly proposed. The latter modelled the relationship between Ca^<2+> density and ATPase activity. The process is modelled as follows : first, electric stimulation (excitation), followed by the release of Ca^<2+> from the sarcoplasmic reticulum, (also taken in by Ca^<2+> pump), the binding of Ca^<2+> at binding sites of troponin, and finally, activation of ATPase between the myosin head and actin filament. The comparison between the experiment and numerical simulation shows difference in the magnitude of force and the characteristics of the time history of force. The former is caused by the difference of size, i. e. , whole muscle in the experiment and the half-sarcomere in the numerical simulation. The latter is due to the incomplete model's of the biochemical reaction process, e. g. , Ca^<2+> density-ATPase relationship.
一般社団法人日本機械学会の論文
1994-10-25