Carcinogenic Effects of Tritiated Water (HTO) in Mice: In Comparison to those of Neutrons and Gamma-rays
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概要
- 論文の詳細を見る
A series of experiments was carried out using female (C57BL/6N×C3H/He)F1 mice (BCF_1) to assess the carcinogenic effect of tritiated water (HTO) following a preliminary experiment in which the acute effect of HTO was studied in young female mice of C57BL/6L strain in an attempt to gain basic information on the long-term experiment, and the results were compared with those of fission spectrum neutrons and gamma-rays. The obtained findings are summarized as follows. 1) C57BL/6N mice receiving a single intraperitoneal (i,p.) injection of HTO, 7.4×10^8 Bq (20 mCi) or more, died of bone marrow failure within 20 days. 2) In long-term experiment, BCF_1 mice given 1.4×10^8 Bq to 5.6×10^8 Bq developed solid tumors in a variety of tissues but with no obvious dose dependency. 3) The fractionated exposure of 7.4×10^8 Bq (1.9×10^8 each, at 7-day intervals) was highly effective in induction of malignant T-cell lymphomas (85%) with a shorter latency than that of a single exposure (15%). 4) A protracted irradiation of 0.27 Gy of ^<137>Cs, designed to simulate the decreasing absorption rate with time after a single i.p. injection of an equivalent dose of HTO resulted in a drastic reduction in induction rate of ovarian tumors as compared with that of an acute ^<60>Co gamma irradiation. 5) The carcinogenic potential of HTO, given as a single i.p. injection, was quite similar to that of acute ^<60>Co gamma ray irradiation at both 2.7 Gy and 0.27 Gy levels. On the other hand, the effect of HTO was slightly higher than that of protracted gamma-ray irradiation. 6) ^<252>Cf fission neutrons was found to be more potent in tumor induction than gamma-rays or HTO beta-rays under the present experimental conditions.
- 日本放射線影響学会の論文
著者
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Yokoro K
Hiroshima Univ. Hiroshima
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Yokoro Kenjiro
Radiation Effects Research Foundation
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Kinomura Aiko
Research Institute For Nuclear Medicine And Biology Hiroshima University
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Seyama Toshio
Depts. Radiobiol. Radiation Effects Res. Foundation
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Seyama Toshio
Radiation Effects Research Foundation
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Seyama Toshio
Department Of Radiobiology Radiation Effects Research Fouondation
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YAMAMOTO OSAMU
Faculty of Science, Hiroshima University
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Seyama Toshio
Dept. Of Radiobiology Rerf.
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Yamamoto Osamu
Facul. Sci. Hiroshima Univ.
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YAMAMOTO Osamu
Facul. , Sci. , Hiroshima Univ.
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