Evaluation of Some Radioprotectors by the Survival Study of Rats Exposed to Lethal Dose of Whole Body Gamma Radiation

元データ 日本放射線影響学会

概要

Survival studies were carried out after 8 Gy whole body gamma radiation (WBGR) in rats treated either with Solcoseryl, β-mercaptopropionyl glycine (MPG), 2-aminoethylisothiuronium bromide hydrobromide (AET), 5-hydroxy L-tryptophan (5-HTP), MPG+5-HTP or AET+5-HTP. The drugs were tested after either oral or i. p. administration in fasted rats. Solcoseryl and the combinations of 5-HTP with AET or MPG rendered excellent protection against 8 Gy but lower survival against 10 Gy WBGR. Oral ingestion of these combinations also gave effective protection against 8 Gy whole body gamma radiation.

著者

Srinivasan M Radiation Biology Division Institute Of Nuclear Medicine &allied Sciences
Ghose A Inst. Nuclear Medicine And Allied Sciences Delhi Ind
BASU S.K. Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences
SRLNIVASAN M.N. Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences
CHUTTANI K. Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences
GHOSE A. Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences
Ghose A. Radiation Biology Division Institute Of Nuclear Medicine &allied Sciences
Basu S.k. Radiation Biology Division Institute Of Nuclear Medicine &allied Sciences
Chuttani K. Radiation Biology Division Institute Of Nuclear Medicine &allied Sciences
Srlnivasan M.n. Radiation Biology Division Institute Of Nuclear Medicine &allied Sciences

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