Urinary Excretion of Creatine and Creatinine in Gamma Irradiated Rats

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Dose response relationships of creatine, creatinie excretions and their ratio in 24 hr urine samples have been studied on each individual day upto 4 days after 1-7 Gy whole body gamma irradiation to rats. Creatine excretion reaches the peak on the 2nd day while creatinine excretion reaches the peak on the first day and a plateau is maintained upto the 4th day in each case. Good dose response correlationship is maintained for creatine or creatinine levels upto the 4th day and for creatine creatinine ratio upto the 3rd day. Seperate dose response curves are needed on each individual day for using these parameters for bio-logical dosimetry purpose. Administration of the radioprotectors viz. , combination of 5-hydroxytryptophan (HT) and 2-amino-ethylisothiuronium bromide hydrobromide (AFT), HI alone and optimum radioprotecting dose of AFT before 5 Gy whole body γ-irradiation have not been of help for reducing creatinineurea. Creatinurea has been reported following large dose of ionizing radiation exposure in various species of animals as also in man 1-8).
日本放射線影響学会の論文