Urinary Deoxycitidine Levels in Radioprotected Rats

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Effect of some radioprotectors on the urinary deoxycitidine (CdR) excretion during first 24 hr after 7 Gy whole body γ-irradiation was studied in rats. The marked increase in CdR excretion due to the 5 Gy irradiation was effectively brought down to a sufficiently low level by pretreatments with (1) combination of hydroxytryptophan (HT) and β-mercaptopropionylglycine (MPG), (2) combination of HT and small dose of 2-aminoethylisothiuronium bromide hydrobromide (AET) and (3) optimum radioprotecting dose of AET. Pretreatments with MPG, HT and the low dose of AET all given singly also lowered the CdR excretion to smaller extents. None of the radioprotectors by themselves had any effect on urinary CdR excretion. The study also confirmed the earlier observation that CdR excretion in urine increased with the dose of whole body irradiation upto 6 Gy. Dische-positive substances in urine increases proportionally to the dose of whole body X-irradiation upto 6 Gy1, 2) Deoxycitidine (CdR) is the main constituent among the DNA degradation products in urine responsible for the Dischle reaction2, 3).
日本放射線影響学会の論文