The Carcinogenic Effects of Fetal and Postnatal Radiation in Female Mice

概要

論文の詳細を見る
The present study was designed to investigate the carcinogenic effects of fetal and post-natal irradiation in female mice. The C57BL/6J mice were subjected to whole-body exposure to 1-Gy or 4-Gy ^<137>Cs γ-ray irradiation on the 15th fetal day or the 30th postnatal day. Following this, all mice were observed through out their respective life spans under conventional rearing conditions. The tumor incidence rate, average latent period and distributions of various tumors were used as the quantitative parameters of radiation-induced carcinogenesis. The following conclusions can be draw: (1) The mean life span of mice that underwent 4-Gy irradiation at the age of 30 days was shorter than that of non-irradiated control mice. (2) In control mice, the tumor incidence was 75.7%. (3) In order to estimate the mean age and tumor incidence, an adjustment for competing death is necessary. (4) The adjusted tumor incidences of thymic lymphoma and breast tumor of the irradiated groups were not different from those of control group. On the other hand, there was a significant difference between the two in the adjusted incidence of reticular tissue neoplasm.
日本放射線影響学会の論文