Recovery Kinetics from the Damage by Step-up and Step-down Heatings in Combination with Radiation in Chinese Hamster Cells

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The recovery kinetics from the synergistic damage resulting from the combination treatments of X-irradiation (3 Gy), and 42℃ (60 min) and 44℃ (15 min) hyperthermia were analized in Chinese hamster V-79 cells. Recovery time was less than about 8 hr when the first treatment was hyperthermia [42℃ (60 min) or 44℃ (15 min)] alone, X-irradiation alone, the combined treatments with the both, or the combined hyperthermia of 42 → 44℃ sequence. However, when the combined hyperthermia of 44 → 42℃ sequence was given as the first treatment, the survival of cells did not attain to the additive level within a 24 hr interval at 37℃. From these results, it is suggested that the damage induced by the combined hyperthermia of 44 → 42℃ sequence was retained partially in the cells during at least a 24 hr interval at 37℃, and may interact synergistically with the damage by the subsequent X-irradiation.
日本放射線影響学会の論文