Responses to Hyperthermia (42°, 44°) and/or Radiation in Four Mammalian Cell Lines in Vitro

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Survival in response to hyperthermia at 42 and 44℃, both alone and in combination with X-irradiation was examined in vitro in Chinese hamster V-79, HeLa-S3, murine Ehrlich ascites tumor cells (EH) and murine L-fibroblasts. L-cells were markedly thermo- and radiosensitive, while the other three cell lines, although not so sensitive did show similar responses. When each cell line was exposed to split dose Hyperthermia in the 42→44℃ sequence, survival after the second treatment was increased for V-79 and HeLa-S3 cells, but was not significantly changed for EH and L-cells. In the case of split dose exposure in the 44→42℃ sequence, survival after the second treatment was markedly decreased for V-79, EH and HeLa-S3 cells, but only slightly for L-cells. When hyperthermia at 42 or 44℃ was followed by X-irradiation immediately, V-79, EH and HeLa-S3 cells showed decrements in both D_q and D_o values, while L-cells showed a decrement only in D_q but no significant change in D_o. From these results, it seems that the hyperthermic damage by exposure to 44℃ may be different from that by exposure to 42℃.
日本放射線影響学会の論文