Response of Mice Liver to Continuous β-Irradiation from Triti ated Water

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The low-level toxicity of the tritium has been studied on the adult mice liver. A group of adult mice was irradiated continuously at the radioactivity of 1.25 μCi/ml of drinklng water up to 30 days and the liver was studied on 1, 5, 7, 15 and 30 days after initiation of treatment. In early intervals, a gradual increase in the degree of damage in the form of histopathological lesions like cytoplasmic vacuolation and degranulation, pycnosis, hemorrhage and lymphocytic infiltration etc. was noticed which reaches to maximum on day 7, after which it was found a bit repaired on the following interval (15 days) and on 30th day exhibited almost a near-normal hepatic architecture with a few histopathological lesions viz. edema and leukocytlc infiltration. Tritium, a naturally occurring heavy isotope of hydrogen, is formed from several interactions of cosmic rays with the gases of upper atmosphere. Moreover, a large quantity of tritium is involved in nuclear energy operations and being a significant by-product of nuclear fission, a major amounts find their way to the environment, thus proving hazarduous to human population, due to a bound gradual increase, from these sources. Recently many reports have drawn attention of reserchers of its low-level toxicity on the different animals and their development.
日本放射線影響学会の論文