Behavior of the Esophageal Mucosa after Radiophosphorous Administration

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Radiopathological study was undertaken on the mucosal layer of esophagus in mice after administration of P-32. Young adult mice were administered with P-32 at the dose rate 5 μCi/g body weight and autopsied at different intervals. An elevation of the mucosal epithelium is noted upto 15 day followed by a decline at 30 day. The number of pyknotic and necrotic cells increas markedly upto day 7 and it reaches to an extremely high levels at 15 and 30 days post-injection. It has beed reported that after exposure of thorax to external radiation, the esophagus responds more quickly and bitterly than trachea and skin. Notwithstanding this, little attention has been paid to this region of the gastro-intestinal tract, considering it to be radio-resistant. Most of the work is done largely with very high doses of external and internal radiations. In our previous communication with low doses of P-32, a gradual elevation of the esophageal mucosa was reported. The elevation was mainly due to the edematous lesions of the stratified epithelium. The present communication looks forward, if esophagus shows the same kind of behavior after a high dose of the radio-nuclide administration.
日本放射線影響学会の論文