Immune Responses In lrradiated Mice I. Radiosensitivity of Antibody Response Against Sheep Erythrocytes In C57BL/6 Mice

概要

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Response to SRBC The effect of whole body irradiation on antibody response to sheep erythrocytes was investigated in C57BL/6 mice. 1) The degree of reduction in antibody production observed shortly after irradiation increased with the increase in X-ray dose. Recovery from the damage of immunocompetent cells was not complete even one month after irradiation. 2) Some mice exposed to 300R or more could not produce antibodies immediately after irradiation. Inability to produce antibodies in these mice may largely be attributable to the damage of B cells, since anti-2, 4, 6-trinitrophenyl (TNP) antibody was produced in all thymectomized mice, when they were irradiated with 300R or more and immunized two months after irradiation. 3) Antibody production ceased in thymectomized mice sooner than non-thymectomized mice irrespective of radiation dose. 4) Neither non-thymectomized nor thymectomized mice could produce lgG antibodies after irradiation of 400R or more. These irradiated mice, however, produced lgG antibody, when 1 x 10^6 activated T cells were transferred together with sheep erythrocytes. These results indicate the inability to produce IgG antibody may be attributable to lack of T cells participating as helper cells in lgG antibody production.
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