Comparative Study of 5-Fluorouracil and Its Derivative, N_1(2'-Tetrahydrofuryl)-5-Fluorouracil on Endogenous Colony Forming Units in Spleens of Mice

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概要

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• The effect of intraperitoneal injection of N_1-(2'-tetrahydrofuryl)-5-fluorouracil (FT-207) which is metabolized to 5-fluorouracil (5-FU) in vivo, on endogenous colony forming units in the spleen (endogenous CFU-s) was observed and compared with that of 5-FU. The 8x 10^<-4>m eqv of FT-207 injected in mice 20 minutes before X-rays irradiation of 450 rads suppressed the endogenous CFU-s count to about 60% and about 5.5x 10^<-5>m eqv of 5-FU had the same effect. The suppression of FT-207 continued over 120 minutes and increased gradually. The effect of 5-FU was strong shortly after the injection but faded out for 120 minutes. FT-207 had almost no effect on the recovery constant (Blair) of endogenous CFU-s for 3 days, whereas 5-FU reduced seriously, especially for the first 2 days. The differences in the effects of both compounds could not be explained on the base of the only differences in the metabolism of both compounds. A compound, N1-(2'-tetrahydrofuryl)-5-fluorouracil (FT-207) was synthesized by Hiller et al. in 1967, as an anticancer compound.

• 日本放射線影響学会の論文

著者

• 上野 陽里

  京都大学医学部放射能基礎医学教室

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