Effect of Halogenated Pyrimidines on Radiosensitivity of Mouse Strain L Cells and Their Radioresistant Variant
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概要
- 論文の詳細を見る
Incorporation of halogen analogs of pyrimidine into DNA of the mouse strain L cells enhanced their sensitivity to X-ray irradiation. The maximal radiosensitization was obtained either with 72 hours, incubation in the presence of BUdR alone or 24 hours' incubation in the presence of BUdR and aminopterin before X-ray irradiation. The replacement of thymidine by BUdR in these optimal conditions was approximately 30 %, and a further increase of the x-eplacement up to 50 % did not intensify the radio-sensitization. These results may support the view that BU-labeling of single strand of DNA double helix is sufficient to confer significant radiosensitization. The radiosensitivity of the resistant Lγ cells was restored by BUdR incorporation up to the same level as that of untreated original cells. These observations would contribute to some extent towards the improvement of radiation therapy.
- 日本放射線影響学会の論文
著者
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青山 喬
滋賀医科大学
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青山 喬
Department Of Experimental Radiology Shiga University Of Medical Science
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菅原 努
京都大学
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菅原 努
Department of Experimental Radiology, Faculty of Medicine, Kyoto University
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青山 喬
Growth Research Institute, Kobe Medical College
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近藤 光雄
Growth Research Institute, Kobe Medical College
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湯川 正克
Department of Experimental Radiology, Faculty of Medicine, Kyoto University
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近藤 光雄
神戸大学医学部放射線基礎医学教室
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湯川 正克
Department Of Experimental Radiology Faculty Of Medicine Kyoto University
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