Biophysical Interpretation on the Biological Actions of Radiations (II) : (On the Examples of the Type-Analysis of the Dose-Survival and the Dose-Effect Curves)
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Based upon the discussion on the analysis of the metabolic switching circuit function with the symbolic logic or Boolean algebra and the multi-target theory described in the previous paper, some of the examples of the type-analysis of the dose-survival curves of E. coli and phages and the theoretical discussions on the dose-effect or dose-mutation curves are introduced in this paper. The delayed expression of mutation, photoreactivation or photoreversal of mutation, and the phenomena that the mutation rate among the survivors increases first with the increase of the dose of radiation but reaches a peak or plateau and sometimes begins to decrease are also discussed. From the exponent of e in the hit functions the average size of the unit particles or target switches may be estimated. In case of the inactivation of E. coli or phages by X-rays, the size of the unit particles appears to approach close to that of the macromolecule of DNA with the reduction of the effective action field of radiation, while in case of the ultraviolet light, some smaller unit equivalent to about 1-20 nucleotides appears to be playing a role of primary importance. Although it appears to be smaller with the radioresistant strain than with the radiosensitive, the size of the unit particle for the ultraviolet light of wavelength 2537 A appears to be equivalent to about 10-20 nucleotides with the radiosensitive strain and with the correction for the attenuation factor inside the cell.
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