Measurement of Cell Kinetic Parameters in Meningiomas
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概要
- 論文の詳細を見る
術後残存髄膜腫の増大速度を評価する目的で、各種パラメーターの算出を行った。術後残存腫瘍の経時的追跡が画像上可能であった髄膜腫4例を対象とした。MIBI抗体にて染色を行い陽性細胞の割合を算出した。同時に画像より腫瘍体積を算出し、腫瘍の生長曲線を作成した。生長曲線よりtumor doubling time(Td)を求め、MIB1陽性率と腫瘍体積よりcell cycle time(Tc)を計算した。最後にpotential doubling time(Tp)の値を、計算したTcを用いて予測した。MIB1陽性率は0.0055から0.0468、Tdは270日から1429日、Tcは10.4日から15.9日であった。Tpは197日から1645日で、実測したTdと近似し、本法によるパラメーターの算出が有用であることが示唆された。
- 日本脳神経外科学会の論文
- 1997-01-15
著者
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Suzuki Kenzo
Department Of Neurosurgery Matsushita Memorial Hospital
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Nakagawa Yoshio
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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Ueda Satoshi
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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SUGAWA Noriaki
Department of Neurosurgery, Kyoto Prefectural University of Medicine
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VIGNUTELLI Alessandra
Department of Toxicology, Drug Safety Assessment, Sandoz Pharma Ltd.
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PERENTES Elias
Department of Toxicology, Drug Safety Assessment, Sandoz Pharma Ltd.
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Sugawa Noriaki
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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Perentes Elias
Department Of Toxicology Drug Safety Assessment Sandoz Pharma Ltd.
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Vignutelli Alessandra
Department Of Toxicology Drug Safety Assessment Sandoz Pharma Ltd.
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Ueda Satoshi
Department Of Electronic Engineering Faculty Of Engineering Kobe University:(present Address)fujitsu
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中川 善雄
Department of Neurosurgery, Kyoto Prefectural University of Medicine
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SUZUKI Kenzo
Department of Neurosurgery, Matsushita Memorial Hospital
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