Human Recombinant Interleukin-1β-mediated Growth Inhibition of Cultured Malignant Glioma Cells
スポンサーリンク
概要
- 論文の詳細を見る
The effect of human recombinant interleukin-1β (hrIL-1β) on tumor growth was studied in eight glioma cell lines. hrIL-1β inhibited growth in all cell lines, but to varying extents. Two cell lines were suppressed by 0.5ng/ml hrIL-1β, and three cell lines required 20ng/ml. hrIL-1β also induced morphological changes and increased F-actin contents. hrIL-1β-treated cells demonstrated multipolar shapes and numerous processes with a greater number of cell-cell contacts 24 hours after treatment. Fluorescence microscopy revealed that these processes contained a large amount of polymerized F-actin. These results suggest that hrIL-1β-mediated growth inhibition may be related to the differentiation of glioma cells.
- 日本脳神経外科学会の論文
- 1993-01-15
著者
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Miyagi Koichi
Department of Neurology, Shinshu University, School of Medicine
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KOGA Hisashi
Department of Neurosurgery, University of the Ryukyus School of Medicine
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NAKASONE Susumu
Department of Neurosurgery, University of the Ryukyus School of Medicine
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HIGA Yasushi
Department of Neurosurgery, University of the Ryukyus School of Medicine
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Mukawa Jiro
Department Of Neurosurgery Osaka University Medical School
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Mukawa Jiro
Department Of Neurosurgery University Of The Ryukyus School Of Medicine
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Mukawa Jiro
Department Of Neurological Surgery Okayama University Medical School
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Koga Hisashi
Department Of Cardiovascular Center Shin-koga Hosipital
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Koga Hisashi
Department Of Neurosurgery University Of The Ryukyus School Of Medicine
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Higa Yasushi
Department Of Neurosurgery University Of The Ryukyus School Of Medicine
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MEKARU Susumu
Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes
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INGRAM Marylou
Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes
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Nakasone Susumu
Department Of Neurosurgery University Of The Ryukyus School Of Medicine
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Mekaru Susumu
Experimental And Clinical Immunotherapy Laboratory Huntington Medical Research Institutes
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Miyagi Koichi
Department Of Neurology Shinshu University School Of Medicine
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Ingram Marylou
Experimental And Clinical Immunotherapy Laboratory Huntington Medical Research Institutes
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MIYAGI Koichi
Department of Neurosurgery, University of the Ryukyus School of Medicine
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Koga Hisashi
Department Cardiology, Sinkoga Hospital, Japan
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