Effects of Dobutamine on Brain Surface Microvessels in Rats

概要

論文の詳細を見る
The effects of dobutamine on the diameters of rat pial vessels were investigated in vivo using a closed cranial window technique. Dobutamine(10^-7-10^-3M)was dissolved in artificial cerebrospinal fluid(CSF). Arterioles(17-78μm in diameter)and venules(20-97μm in diameter)were observed through the cranial window over the left parietal cortex. Superfusion of the brain surface with only artificial CSF had no effect on vessel diameter. Dobutamine,even at a high concentration of 10^-4M,did not induce significant diameter changes in the pial vessels,compared with control animals. The arterioles showed marked dilatation(+73%)during superfusion with 10^-3M dobutamine(p<0. 01 vs. control). The venules were also dilated(+12%),although the increased diameter was not statically different from controls. Therefore,dobutamine did not induce a dose-dependent dilation. The results strongly suggest that dobutamine at clinical dosages does not have a direct vasomotor effect on brain microvessels.
日本脳神経外科学会の論文
1998-03-15