先天性胆道閉鎖症における胆汁分泌機構の検討 : 第2報主に利胆剤の影響

概要

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This stdudy was performed in order to examine the response to choleretic agents (dehydrocholic acids, glucagon and secretin) and the mechanisms of bile secretion which was normal or not in CBA. Seven children who had undergone so called Suruga II porto-jejunostomy were studied. The effect were calculated as follows; we required the ratio of the mean volume after admistration of choleretic agents to an average volume before its admistration. Bile volume increased by administration of any of the drugs, especially synchronous three drugs medication (1.474±0.350) and glucagon alone (1.416±0.630). Secrected bile bilirubin decreased by almost all choleretic drugs, but secretin alone. So combined medication obstructed bile bilirubin secretion (0.5〜0.6). Secreted bile acid increased by dehydrocholic acid (1.2〜1.75), but glucagon and secretin had no effect on bile acid secretion. These response to choleretic agents suggest that the mechanisms of bile secretion was almost normal in the postoperative patients.
日本小児外科学会の論文
1985-10-20