SENSITIZED T LYMPHOCYTES AGAINST PATERNAL HISTOCOMPATIBILITY ANTIGENS CAUSE INTRAUTERlNE FETAL DEATH AND GROWTH RETARDATION
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概要
- 論文の詳細を見る
胎児・胎盤は父親由来の組織適合抗原を有している.母体のあるものはこの父親由来の組織適合抗原に対して細胞性免疫および液性抗体を産生する.これらの細胞性免疫あるいは液性抗体が胎児・胎盤に作用し障害を与え,免疫学的に流死産を起こし得る.我々は組織適合抗原の確立している近交系マウスを用いて免疫学的流死産の実験モデルを作製し検討を行い,父方組織適合抗原に対する細胞性免疫が免疫学的流死産の主体であることを示した.細胞性免疫にはT細胞とB細胞の2種のsubpopulationが存在している.今回父方組織適合抗原に対する細胞性免疫のうちT細胞に富んだsubpopulationを作製し,これが免疫学的機序による流死産を起こし得るか否かについて以下の実験を行なった.父方組織適合抗原に対する感作脾細胞は近交系C57BL/6Jマウスに組織適合抗原の異なるC3H/Heマウスの皮膚移植および脾細胞による腹腔内免疫を行ない作製した.この感作脾細胞を補体存在下で精製山羊抗M104E抗血清と作用させ,B細胞を除去しT細胞に富んだ細胞浮遊液を作製した.C3H/Heの組織適合抗原に対する感作T細胞浮遊液をC3H/Heオスマウスとmakingして妊娠したC57BL/6Jメスマウスの妊娠第7日に尾静脈から投与した.妊娠第18日に開腹し,子宮内胎仔死亡の有無,胎仔数,胎仔重量,胎盤重量について検討した.その結果感作T細胞投与により流死産率が上昇し(実験群23.6%,対照群3.8%),生存胎仔重量の有意な低下をみた(実験群833±139mg,対照群1,019±182mg).胎盤重量には変化がみられなかった(実験群131±18mg,対照群129±16mg).
- 1980-11-01
著者
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Saji Fumitaka
Department Of Obstetrics And Gynecology Osaka University Medical School Osaka
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NEGORO Takao
Department of Obstetrics and Gynecology, Osaka University Medical School
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WAKAO Toyokazu
Department of Obstetrics and Gynecology, Osaka University Medical School
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NAKAMURO Karo
Department of Obstetrics and Gynecology, Osaka University Medical School
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Negoro Takao
Department Of Obstetrics And Gynecology Osaka University Medical School
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Negoro T
Osaka Univ. Osaka Jpn
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Nakamuro K
Department Of Obstetrics And Gynecology Osaka University Medical School
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Nakamuro Karo
Department Of Obstetrics And Gynecology Osaka Prefectural General Hospital
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Wakao Toyokazu
Department Of Obstetrics And Gynecology Osaka University Medical School
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Saji Fumitaka
Department Of Obstetrics And Gynecology Osaka University Medical School
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