CIRCULATING IN THE AUTOANTIBODIES AGAINST SPERMATOZOA HUSBANDS OF INFERTILE COUPLES
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概要
- 論文の詳細を見る
Vasectomyを行なった男性の約半数に自己抗精子抜体が検出される。これはvasectomyによって障害された性管から精子,精漿等が血中に流出する結果自己抗体が産生されたものと思われる。vasectomyを行なっていない正常男性においても炎症等によって自己杭精子抗体が産生された場合には妊孕性が失われ,その夫婦が不妊になる可能性がある.我々は不妊夫婦39組(無精子症9例,乏精子定12例,精液検査正常例18例)の夫及び妻の血中抗精子抗体を精子不動化試験を用いて測定し,精液検査及びpostcotal testの成績と比較検討を行なった。その結果、(1)39例の夫のうち2例(5.1%)の血清中に自己抗精子抗体を認めた。[○!2]自己抗精子抗体陽性例のうち1例は精液検査が正常(精子数8x10^7/ml)から無精子症になった症例であった.他の1例は精液検査で乏精子症(精子数2.3x10^7/ml)を示し,精子運動率も低かった(40〜50%).[○!3]自己抗精子抗体陽性例2例のpostocotial testの成績はいずれも不良群に属した.夫が自己抗精子抗体を有した場合,その夫婦が不妊になる機序としては第一に自己抗精子抗体が造精器官に直接作用しspermatogenesisを阻害することが考えられる,第二に精漿中に移行した自己抗精子抗体によって射精された精子が凝集を起こし,その結果子宮茎管粘液への通過性が不良になると考えられる.
- 1979-04-01
著者
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Saji Fumitaka
Department Of Obstetrics And Gynecology Osaka University Medical School Osaka
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NEGORO Takao
Department of Obstetrics and Gynecology, Osaka University Medical School
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WAKAO Toyokazu
Department of Obstetrics and Gynecology, Osaka University Medical School
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NAKAMURO Karo
Department of Obstetrics and Gynecology, Osaka University Medical School
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Kurache Keiichi
Department of Obstetrics and Gynecology, Osaka University Medical School
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YAGI Junko
Osaka and Osaka Telbhin Hospital, Osaka
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Yagi Junko
Osaka And Osaka Telbhin Hospital Osaka
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Negoro Takao
Department Of Obstetrics And Gynecology Osaka University Medical School
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Negoro T
Osaka Univ. Osaka Jpn
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Nakamuro K
Department Of Obstetrics And Gynecology Osaka University Medical School
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Nakamuro Karo
Department Of Obstetrics And Gynecology Osaka Prefectural General Hospital
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Wakao Toyokazu
Department Of Obstetrics And Gynecology Osaka University Medical School
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Saji Fumitaka
Department Of Obstetrics And Gynecology Osaka University Medical School
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Kurache Keiichi
Department Of Obstetrics And Gynecology Osaka University Medical School
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