当科における悪性卵巣腫瘍の妊孕性温存治療症例の検討

概要

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Twenty seven ovarian malignancies (15 epithelial tumors, 1 granulosa cell tumor, and 11 germ cell tumors) with conservative treatment were investigated in terms of prognosis and fertility. The FIGO stages were Ia in 12 cases, Ic in 8, II in 3 and III in 4. Sixteen patients were receiving CDDP (mean dose, 426.9mg) -based chemotherapy. Fourteen of them resumed ovulation within 6 months after discontinuing the chemotherapy. Five patients delivered at a mean of 66.6 months after surgery and 4 of them had received chemotherapy and 3 had undergone SLO. The survival rate was 100% over a follow-up period with a median of 77.7 months. In conclusion, conservative treatment with adjuvant chemotherapy may be appropriate for epithelial tumors graded at less than stage Ic (b) and for germ cell tumors at stage II or higher. CDDP at a dose up to 400mg apperaed not to have an adverse effect on the patient's fertility.
社団法人日本産科婦人科学会の論文
2001-10-01