血漿総レニン濃度の腫瘍マーカーとしての診断的意義に関する基礎的評価

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No tumor marker specific for Wilms' tumor has been known until recently. However, we had reported that plasma total renin can be a useful marker for Wilms' tumor. Plasma total renin was measured in our study by a radioimmunoassay system, which uses a monoclonal antibody specific for both active and inactive renin, and is simpler than conventional methods. Usually total renin concentration is measured by plasma samples. Not only plasma samples but also serum samples were taken from 19 subjects at the same time. The values in sera were found to be uniformly lower than those in plasmas, and a regression line, y=1.107x-1.058, r=0.999, was obtained, where y is value in plasma and x is that in serum. The high coefficient of this regression line indicates the possibility of measuring and interpretating values in serum samples, stored elsewhere. Total renin value in patients with Wilms' tumor was higher than the upper border of the normal ranges (301pg/ml) in 13 of the 25 cases. In other words, it should be noted that the value was within the normal ranges in about half of Wilms' tumor although there remain some problems in interpretating the data from stored serum samples. Plasma total renin concentration in a patient with congenital mesoblastic nephroma showed the highest value when compared with plasma total renin concentrations in patients with Wilms' tumor. Plasma total renin was lower than the upper border of the normal ranges in all patients with neuroblastoma. Some cases of hepatoblastoma and ovarian teratoma showed the exceedingly high plasma total renin concentration, and such high values may be attributed to extra-renal production of prorenin.
日本小児外科学会の論文
1992-10-20

血漿総レニン濃度の腫瘍マーカーとしての診断的意義に関する基礎的評価

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