IN VITRO EFFECT OF SOME FREE ESTROGENS OR ESTROGEN PRECURSORS ON COLLAGENASE ACTIVITY OF UTERINE CERVIX

概要

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In order to determine whether or not collagenase activity of the uterine cervix can be influenced by estrone (E_1), estradiol (E_2), estriol (E_3), equilin, dehydroepiandrosterone sulfate (DHA-S) or dehydroepiandrosterone (DHA), the collagenase activity of extract of connective tissue of the uterine cervix treated with the drug was measured. A higher collagenase activity was obtained in pregnant cervix than that in nonpregnant ones. These was no difference in collagenase activity of the uterine cervix extract between control and drug (5×10^<-5> M of E_1 E_2 E_3 equilin, DHA-S or DHA) groups both in nonpregnant and pregnant conditions. After preincubation of tissue with 1 × 10^<-5> M of the said drug at 37℃ for 60 min, the enzyme activity of the supernatant was also investigated. In nonpregnant conditions, no increase in the enzyme activity was observed. On the contrary, significant increase of the enzyme activity was obtained in pregnant uterine cervix preincubated with equilin, E_3, DHA-S or DHA comparing to that of control group. However, these increase was not observed by E_1 or E_2. Elastase activity was also investigated on cervical connective tissue both in nonpregnant and pregnant conditions. No increase in elastase activity was observed in the pregnant cervix comparing to that of nonpregnant group.
社団法人日本産科婦人科学会の論文
1981-06-01