THE MECHANISM OF HORMONAL RECEPTOR REGULATION IN THE RAT OVARY FOLLOWlNG ADMINISTRATION OF GONADOTROPlN AND PROLACTIN
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概要
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高prolactin, 高gonadortropin血症における卵巣の反応性の変化を明らかにする目的で,ラットに各種ホルモンを投与し,卵巣のLHとprolactin両レセプター(LH-r,PRL-R)および末梢血中のestradiol,progesterone産性能の変動を比較検討した.90日齢の成熟雌ラットに生理食塩水(対照群),ovine prolactin(oPRL;1IU),hCG(10IU),hMG(20IU)を四日間,さらにoPRL(1IU),hCG(10IU),oPRL(1IU)+hCG(10IU)を8日間投与した.卵巣LH-R活性はoPRL,hCGの4日間投与で対照群のそれぞれ60,63%に減少した.8日間の投与ではLH-RはoPRL,hCG,oPRL+hCGの各群で対照群のそれぞれ53,44,37%に減少した.PRL-R活性はoPRL負荷で変動せず,hCGの4日間負荷で増加し,8日間負荷で正常範囲となった.血中estradiolはoPRL投与で減少し,hCG,hMGの投与で対照群のそれぞれ2,9倍に上昇した.血中progesteroneはoPRL,hCG投与群で変性卵胞と間質の増殖が目立った.以上より高prolactin血症において,高レベルのprolactinは卵巣LH-Rをdown-regulateし,アロマターゼ活性を抑制する.このことは本症の内分泌療法時ホルモン投与に対する卵巣の不応性の重要な因子と考えられる.
- 社団法人日本産科婦人科学会の論文
- 1987-03-01
著者
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Maki Masahiro
Department Of Obstetrics And Gynecology Akita University School Of Medicine
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太田 博
Department Of Obstetrics Aud Gynecology Akita University School Of Medicine
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Maki Masahiro
Department Of Obstetrics Aud Gynecology Akita University School Of Medicine
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FUKUSHIMA Mineko
Department of Obstetrics aud Gynecology, Akita University School of Medicine
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Fukushima Mineko
Department Of Obstetrics Aud Gynecology Akita University School Of Medicine
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