腸管大量切除後の残存腸管における代償機能の実験的研究 : 第2報,腸管オルニチン脱炭酸酵素の変動を中心として

概要

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The activity of ornithine decarboxylase (ODC) which catalyses the first step of polyamine Synthesis is expected to increase in the remaining bowel after massive intestinal resection in rat as well as observed in the partially resected liver and in the healing skin wound of rat. The ODC activity was highest in the upper jejunum and lower in the ileum in unoperated rat. After resection of 80% of the small intestine, the ODC activity of the proximal (duodenum and upper jejunum) and distal segment (lower ileum) increased very rapidly and reached maximum after 12 hours. The peak activity in the proximal segment was 3 times and that of distal segment was 43 times higher than the level of unoperated rats. These findings suggest that adaptation of the distal segment was greater than that proximal segment after massive intestinal resection. The increase of ODC activity in the remaining bowel was related to the amount of resected bowel. But the concentration of polyamine did not increase in the remaining bowel after resection. Although ODC activity of the lower ileum in operated rats increased only slightly by feeding, a marked increase of the enzyme activity was observed in the hyperplastic distal segment by feeding, 3 weeks after massive intestinal resection.
日本小児外科学会の論文
1980-10-20