AMINO ACID UPTAKE AND RELEASE IN RELATION TO THE ACTIVITIES OF GAMMA-GLUTAMYLTRANSPEPTIDASE IN THE FETUS AND AT FETO-MATERNAL JUNCTION

概要

論文の詳細を見る
The concentration of amino acids and activities of gamma-Glutamyltranspeptidase (γ-GTP) in the sera of the maternal antecubital vein (M.V.), the umbilical artery (U.A.) and the umbilical vein (U.V.) were studied in healthy pregnant women at term delivery. Serum γ-GTP activities in the U.A. and the U.V. were significantly higher than in the M.V.. Each amino acid level in the U.A. and the U.V. was significantly higher than in the M.V. except for aspartic acid + asparagine and for arginine. Glutamic acid + glutamine, aspartic acid + asparagine, glycine, methionine and serine were significantly higher in the U.A. while alanine, valine and isoleucine were significantly higher in the U.V.. In the U.V. alanine and serine showed a significantly negative correlation with the activities of γ-GTP but glutamic acid + glutamine showed a positive correlation. In the U.A. glutamic acid + glutamine showed a positive correlation with the activities of γ-GTP but alanine showed a significantly negative correlation. These results suggest that the higher the level of γ-GTP activity present in the umbilical artery the greater the uptake of alanine and the release of glutamic acid + glutamine that occurs in the fetus. A postulate may be made that the placenta accumulates alanine and serine with γ-GTP releasing glutamic acid + glutamine.
社団法人日本産科婦人科学会の論文
1978-09-01