術前 L-TAE が有効であった小児肝悪性腫瘍の2例

概要

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A 12-year-old boy with hepatocellular carcinoma (HCC) and 2-year-old boy with poorly differeutiated hepatoblastoma were primarily treated with transcatheter arterial chemoembolization with lipiodol and adriamycin (L-TAE) , because their tumors were diagnosed unresectable at the time of admission. Hepatectomies with tumors were successfully performed one month and two months after L-TAE, respectively, with marked shrinkage of the tumors and decrease of AFP levels in sera. In the patient of HCC, serum AFP decreased to normal levels 50 days after left hepatectomy, and he is doing well without evidence of disease for 3 years. In the child with hepatoblastoma, L-TAE was performed in 3 times. Although, he is now undergoing an aggressive chemotherapy for lung metastases, AFP levels in sera indicate around 50ng/ml. L-TAE has widely been used in adults for the treatment of HCC with favorable results. However, L-TAE seems to be performed infrequently in infants and children with hepatic malignancy. Our data suggest that L-TAE can be reduced tumor size in short-term, and facillitates radical hepatectomy for primary hepatic malignancies in childhood.
日本小児外科学会の論文
1992-12-20