消化管粘膜の発育におよぼすプロラクチン作用の実験的研究

概要

論文の詳細を見る
In order to investigate the role of prolactin in the growth of intestinal mucosa, we experimentally produced endocrinological enviroments of prolactin secretion in hyperprolactinemia and hypoprolactinemia by administration of bromocriptine or perphenazine to mice. The results were as follows : 1) These administrations induced no change in the gastrointestinal muscle coats as opposed to in its mucosa. 2) The small bowel mucosa tended to grow to the lagest in the hyperprolactinemia group, followed by the controls and the hypoprolactinemia group in that order (p < 0.05). 3) There was no apparent correlation between prolactin secretion and gastric and large bowel mucosa. We conclude that prolactin may be trophic to the intestinal mucosa in mice, suggesting a growth promoting role of prolactin on the mid gut epithelium in the fetal stage.
日本小児外科学会の論文
1992-06-20