ラット先天性および実験的 Aganglionosis 腸管における Substance P と Vasoactive Intestinal Polypeptide の局在 : 組織学的観察

概要

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Localization of substance P (SP) and vasoactive intestinal polypeptide (VIP) in intestinal segments of congenitally and experimentally aganglionic rats were examined using immunohistochemical methods. 1. In the ileum and colon of the normal rats: SP- and VIP-positive (P) axonal terminals surrounding nerve cells and SP- and VIP-P fibers interconnecting nerve cells in the plexuses of my enteric (Au) and submucosal (Me) were observed. In the enlarged intestinal segment of aganglionic rats; SP- and VIP-activities in the Au and Me were normal. In the enlarged segment neighboring on the histologically transitional segment, a definite increase in VIP-P nerve cells in the Me and a slight increase in VIP-P fibers in the circular muscle layer were observed. In the transitional segment, SP- and VIP-P nerve cells in the Au and Me and SP- and VIP-P fibers in the circular muscle layer were reduced. In the aganglionic segment, SP-activity was totally lost in the whole layer, while a few VIP-activities were noted in the circular muscle and mucosal layers at the portion neighboring on the transitional segment, but the activity disappeared in the mucosal layer at first, then did in the whole layer. 3. In the aganglionic colon of experimental aganglionosis, which was produced by previously described method: SP- and VIP-activities were lost totally in the whole layer.
日本小児外科学会の論文
1986-12-20