血清 Bilirubin 抱合体の高速液体クロマト分析による先天性胆道閉鎖症の診断

概要

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The possibility to differentiate congenital bile duct atresia (CBA) from the other neonatal hyperbilirubinemia has been explored by detecting the bilirubin conjugate "C" in serum. The bilirubin conjugate "C" was reported to be the major bilirubin conjugate in normal human bile as evidenced by high-performance liquid chromatographic analysis by Yamaguchi, et al. (1979), and further shown to be never detected in normal human serum. In the present investigation, the bilirubin conjugate "C" determination was carried out in 12 patients of infantile hyperbilirubinemia. Four of 12 patients were congenital bile duct atresia and three of these four were positive to the bilirubin conjugate "C". Evidence hitherto obtained indicated that the detection of the bilirubin conjugate "C" in serum of icteric babies by means of high-performance liquid chromatography seems to be a clue to differentiate congenital bile duct atresia from the other neonatal or infantile jaundice.
日本小児外科学会の論文