膵胆管合流異常の生化学的a理学的検討

概要

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Eleven cases of anomalous arrangement of the pan-creatico-biliary ductal system were studied biochemically and histopathologically including three cancerous lesion. Amylase levels in the bile as well as tripsin levels were extremely high in 7 cases out of nine. In the bile of choledochal cysts without cancer, deoxycholic acid fractions were increased, compared to those of the bile in the cholelithiasis with normal pancreatico-biliary union. In the bile with the cancer arising from the congenital cystic dilatation, taurodeoxycholic acid (TDCA) was increased. Lithocholic acid fractions (LCA) were increased in the bile with the bile duct cancer arising from the cylindrical dilatation as well as in the bile with the gallbladder carcinoma without biliary dilatation. The increasing of DCA and LCA were supposed to be a causative factor of biliary cancer with anomalous union, because these bile acid fractions are known to have the promoting effect on colon carcinogenesis. CEA was demonstrated in the cancer nest by an immunohistochemical staining method. CA19-9 was stained both in the cancerous part and in the non-cancerous epithels.
日本小児外科学会の論文
1989-02-20