Swelling Controlled Release of Drug from Polymetric Delivery Devices: A Local Similarity Solution : General Physics
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概要
- 論文の詳細を見る
This paper presents a numerically integrated solution of moving boundary problems involving mass diffusion in polymer-penetrant system with a swelling controlled release of drug. Dividing the diffusion process into a finite number of fixed boundary problems, we have assumed the local similarity assumption to valid during the short period. Unlike the existing parameter expansion methods, the present solution is expected to be valid over a large range of control parameter representing the difference between solvent concentration at interface and the equilibrium value within the polymer. At small times, our numerical result shows that a larger values of the control parameter leads to a shorter interval for zero order drug release providing a higher release rate.
- 社団法人日本物理学会の論文
- 2000-07-15
著者
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HWANG Chi-Chuan
Department of Engineering Science, National Cheng Kung University
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Hwang Chi-chuan
Department Of Engineering Science National Cheng Kung University
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Hwang C‐c
National Cheng Kung Univ. Tainan Twn
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HSIEH Jin-Yuan
Department of Mechanical Engineering,Nan Ya Junior College
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Hsieh Jin-yuan
Department Of Mechanical Engineering Minghsin Institute Of Technology
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Lee Shio-chao
Department Of Electronic Engineering Minghsin Institute Of Technology
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LlN Jenn-Sen
Department of Mechanical Engineering, Lien-Ho Institute of Technology
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Lln Jenn-sen
Department Of Mechanical Engineering Lien-ho Institute Of Technology
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Lin Jenn-Sen
Department of Mechanical Engineering, Lien-Ho Institute of Technology
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