漸増負荷運動中における非代謝性CO_2排出量の評価の信頼性

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It is known that lactic anions andhydrogen ions (H^+) produced during intense exercise are partly transported or diffused from muscle to blood resulting in the production of non-metabolic CO_2 through the bicarbonate buffering system. The purpose of the present study was to examine the reliability of the estimation of non-metabolic CO_2 output using respiratory gas analysis during incremental exercise. Six healthy subjects underwent an incremental pedaling exercise test accompanied by respiratory gas and arterial blood sampling. The rate of non-metabolic CO_2 output (VCO_2-NM) was calculated by subtracting projected metabolic VCO_2 from actual VCO_2 after CO_2 threshold (CT). CT was determined using a modified V-Slope method. Bicarbonate (HCO_3^-), pH, CO_2 partial pressure and lactate concentration were measured from arterial blood samples using automatic analyzers. The kinetics of VCO_2-NM and HCO_3^- were compared throughout the exercise test. VCO_2-NM was significantly correlated with HCO_3^- decrease after CT (r=0.976, p<0.001) and the kinetics of VCO_2-NM and HCO_3^- decrease were similar during exercise. Furthemore, the amount of non-metabolic CO_2 output (NM-CO_2) calculated integrating VCO_2-NM above CT was significantly correlated with the difference in HCO_3^- between CT and exhaustion (r=0.929, p<0.01) and with the difference in arterial blood pH between rest and exhaustion (r=0.863, p<0.05). However, NM-CO_2 was not significantly related to maximum ventilation (r=0.111, ns). These results suggest that the estimation of non-metabolic CO_2 output during incremental exercise proposed in the present study is reliable. It was also suggested that the primary factor which influenced non-metabolic CO_2 output during incremental exercise was the addition of H^+ into blood and not hyperventilation.
日本体力医学会の論文
2001-02-01

漸増負荷運動中における非代謝性CO_2排出量の評価の信頼性

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