Laminin-5 γ2 Chain and Matrix Metalloproteinase-2 Expression in the Neoplastic Changes of Uterine Cervical Squamous Epithelium

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概要

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• Laminin-5 is an essential component of epithelial basal membranes. Matrix metalloproteinase-2 (MMP-2) changes laminin-5 from static to migratory substrate by cleaving the short arm of the γ2 subunit of the laminin-5. Recently, the expression of laminin-5 γ2 chain has been reported to be a marker of invasiveness of epithelial malignant tumors. We investigated the expression of laminin-5 γ2 chain and MMP-2 in the neoplastic changes of uterine cervical squamous epithelium. Tissue samples of normal uterine cervix, cervical intraepithelial neoplasia-1, -3 (CIN-1, -3) and squamous cell carcinoma keratinizing (SCC-K) and non-keratinizing (SCC-NK) were analyzed for expression of the laminin-5 γ2 chain and MMP-2 by immunohistochemistry. In normal uterine cervix and CIN-1, laminin-5 γ2 chain was immunolocalized only in the basal membrane. In CIN-3, expression of laminin-5 γ2 chain and MMP-2 became apparent at the epithelial-stromal interface of epithelial cells. In SCC-K and SCC-NK, laminin-5 γ2 chain and MMP-2 expression were abundant at the epithelial-stromal interface of tumor clusters. These results suggest that the expression of laminin-5 γ2 chain and MMP-2 may be involved in the process of neoplastic changes of uterine cervical squamous epithelium.

• 神戸大学の論文

著者

• Motoyama Satoru

  神戸大学 医学系研究科産科婦人科学教室

• Motoyama Satoru

  Kobe University Graduate School Of Medicine

• Maruo Takeshi

  神戸大学 医学系研究科産科婦人科学

• Maruo Takeshi

  Kobe University Graduate School Of Medicine

• Maruo T

  Kobe Univ. Graduate School Of Medicine Kobe Jpn

• Malina Robin

  Kobe University Graduate School of Medicine

• Hamana Shinya

  Kobe University Graduate School of Medicine

• Maruo Takeshi

  Kobe University School Of Medicine

• Hamana Shinya

  Kobe University School Of Medicine

• Maruo Takeshi

  Department Of Obstetrics And Gynecology Kobe University

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