Minireview : The Role of Human Papilloma Virus in the Molecular Biology of Cervical Carcinogenesis

概要

論文の詳細を見る
Research exploring the E6-p53 and E7-pRb model has resulted in the identity of theviral gene's actions on numerous cellular proteins and processes normally involved incell growth and proliferation. Specially, several findings have established the variousways by which the HPV-infected cell may escape controls governing cell growth andproliferation, including the fidelity of the host cell's genome and apoptosis.A large body of knowledge already generated in this area supports the view thathigh-risk HPV types have the ability to transform cells into a malignant phenotype.Such ability, however, is not sufficient to actually and inevitably produce cervicalcarcinoma, as indicated by the frequent spontaneous clearance of HPV infection andthe long delay between the onset of persistent infection and emergence of themalignancy. Delay in the participation of cofactors has been suggested as explanation inthis regard. However, it remains unclear how and when cofactors or factors that areinnate in the HPV-infected cells launch the host cells into an irreversible progression tocarcinoma.
神戸大学の論文