Place of Death of Pediatric Cancer Patients in a Single Institute during 7 Years
スポンサーリンク
概要
- 論文の詳細を見る
Place of death is an important issue at the end-of-life. It is poorly understood in pediatric cancer patients in Japan. This study aimed to clarify place of death of children with cancer as well as variables associated with place of death. Study population was pediatric cancer patients who died in the Department of Pediatrics at Kobe University Hospital during the last 7 years. The medical records were retrospectively reviewed regardless of cause of death to derive data relating to patients’ characteristics and disease. 18 patients were included. Median age at death was 12.2 years old. 6 patients including 5 children in complete remission had hematological disease and 12 patients suffered from solid tumors. 4 patients (22.2%) died at home, whereas 14 patients (77.8%) died in the hospital including 6 ICU deaths. No one died in hospices. Preference of patients was unavailable due to the lack of inquiry. Factors influencing place of death (home, ICU, non-ICU) were disease (hematological disease vs. solid tumor, p=0.010, brain tumor vs. non-brain tumor, p=0.023), disease status (complete remission vs. non-complete remission, p=0.0014) and preference of families (p=0.029). Among 6 families who expressed preference, no disparity was observed between actual and preferred place of death. This is the first English publication of place of death of pediatric cancer patients in Japan. The low percentage of home death, factors influencing place of death and the lack of disparity between actual and preferred place of death were indicated. Further studies are required to better understand place of death.
- 神戸大学医学部の論文
著者
-
Maruo Takeshi
神戸大学 医学系研究科産科婦人科学
-
Maruo T
Kobe Univ. Graduate School Of Medicine Kobe Jpn
-
Yamasaki Takemi
Hyogo Prefectural Children's Hospital
-
Takeshima Y
Hyogo Prefectural Children's Hospital
-
Yamamoto Tomoto
Department Of Epidemiology Kobe University Graduate School Of Medicine
関連論文
- ベトナム人脊髄性筋萎縮症患者におけるSMN2遺伝子量ならびにNAIP遺伝子量について
- Clinical Types, Molecular Genetic Diagnosis & Genetic : clinical Correlation in Patients with Spinal Muscular Atrophy
- Deletion of the SMN1 and NAIP Genes in Vietnamese Patients with Spinal Muscular Atrophy
- Molecular Genetic Analyses of Five Vietnamese Patients with Spinal Musucular Atrophy
- Complete skipping of exon 66 due to novel mutations of the dystrophin gene was identified in two Japanese families of Duchenne muscular dystrophy with severe mental retardation
- Molecular Diagnosis, Correlation of Clinical and Deletion Data in Duchenne Muscular Dystrophy
- Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation
- Minireview : The Role of Human Papilloma Virus in the Molecular Biology of Cervical Carcinogenesis
- Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
- 4-10.Gleevec Sensitizes Ovarian Cancer Cells to CDDP(Session 5 Oncology 5)
- 1-17.Immunohistochemical demonstration of elevated expression of Laminin-5γ2 chain and MMP-2 in the neoplastic changes of cervical squamous epithelium.(Session 1 Oncology 1)
- Laminin-5 γ2 Chain and Matrix Metalloproteinase-2 Expression in the Neoplastic Changes of Uterine Cervical Squamous Epithelium
- IS-5 Effects of EGF on chemosensitivity of cervical squamous carcinoma cells (CaSki) to cisplatin (DDP) and actinomycin-D (ACT-D)
- Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma
- Implications of adrenomedullin expression in the invasion of squamous cell carcinoma of the uterine cervix
- Expression of Fas/Fas-Ligand, Bcl-2 Protein and Apoptosis in Extravillous Trophoblast along Invasion to the Decidua in Human Term Placenta
- IS-63 Effects of L-triiodothyronine(T3)on Cell Survival and Fas/Fas ligand Expression in Cultured Early Placental Extravillous Trophoblasts(EVT)
- Changes in Proliferative Potential, Apoptosis and Bcl-2 Protein Expression in Cytotrophoblasts and Syncytiotrophoblast in Human Placenta over the Course of Pregnancy
- IS-39 EFFECTS OF LEVONORGESTREL-RELEASING INTRAUTERINE DEVICE (LNg-IUD) ON THE ENDOMETRIUM
- IS-12 Effect of IGF-I on PCNA and Bcl-2 Protein Expression in Uterine Leiomyoma Cells
- IS-10 Direct effects of GnRH agonist on Human Uterine Leiomyoma Cells : Suppression of Cell Proliferation and Induction of Apoptosis
- 良性家族性新生児痙攣を有する日本人一家系内の生殖細胞に生じたKCNQ2遺伝子変異(p. R213W)
- A Strong Exonic Splicing Enhancer in Dystrophin Exon 19 Achieve Proper Splicing Without an Upstream Polypyrimidine Tract
- Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy
- Mutation Analysis of the Ornithine Transcarbamylase (OTC) Gene in Five Japanese OTC Deficiency Patients Revealed Two Known and Three Novel Mutations Including a Deep Intronic Mutation
- Mosaic Tetrasomy 9p Case with the Phenotype Mimicking Klinefelter Syndrome and Hyporesponse of Gonadotropin-Stimulated Testosterone Production
- Nobel cryptic exons identified in introns 2 and 3 of the human dystrophin gene with duplication of exons 8-11
- Prenatal diagnosis of a Japanese family at risk for tay-sachs disease : application of a fluorescent competitive allele-specific polymerase chain reaction (pcr) method
- Immunological evidence for the expression of Na/K-ATPase in the porcine ovary during follicular growth and regression(Session18 Reproduction4)
- Transfection of antisense-CGβgene into choriocarcinoma suppressed the cell proliferation and induced apoptosis(Session15 Oncology7)
- Thyroid Hormone Synergizes with Follicle Stimulating Hormone to Inhibit Apoptosis in Porcine Granulosa Cells Selectively from Small Follicles
- IS-55 Na^+/K^+-ATPase Activity in Porcine Granulosa Cells is Closely Related to the Cell Proliferation and Apoptosis
- IS-49 EFFECTS OF EPIDERMAL GROWTH FACTOR ON THE ENZYMATIC ACTIVITY OF NA^+/K^+-ATPase IN PORCINE GRANULOSA CELLS DURING FOLLICULAR GROWTH
- Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients
- Comparative study on deletions of the dystrophin gene in three Asian populations
- A novel cryptic exon in intron 3 of the dystrophin gene was incorporated into dystrophin mRNA with a single nucleotide deletion in exon 5
- Molecular genetics of spinal muscular atrophy : contribution of the NAIP gene to clinical severity
- Oligonucleotides against a splicing enhancer sequence led to dystrophin production in muscle cells from a Duchenne muscular dystrophy patient
- Purine-rich exon sequences are not necessarily splicing enhancer sequence in the dystrophin gene
- Non-homologous recombination between Alu and LINE-1 repeats caused a 430-kb deletion in the dystrophin gene : a novel source of genomic instability
- A simple explanation for a case of incompatibility with the reading frame theory in Duchenne muscular dystrophy: failure to detect an aberrant restriction fragment in Southern blot analysis
- Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center
- IS-42 Expression of single chain luteinizing hormone analogue
- Intraperitoneal administration of phosphorothioate antisense oligodeoxynucleotide against splicing enhancer sequence induced exon skipping in dystrophin mRNA expressed in mdx skeletal muscle
- SMN2 and NAIP gene dosages in Vietnamese patients with spinal muscular atrophy
- A Homozygous Mutation in UGT1A1 Exon 5 May Be Responsible for Persistent Hyperbilirubinemia in a Japanese Girl with Gilbert’s Syndrome
- Persistent detection of a novel MLL-SACM1L rearrangement in the absence of leukemia
- Utility of Multiplex PCR in Detecting the Causative Pathogens for Pediatric Febrile Neutropenia
- Fatal degeneration of specialized cardiac muscle associated with chronic active Epstein-Barr virus infection
- 先天性全身性脂肪萎縮症の2乳児例
- Place of Death of Pediatric Cancer Patients in a Single Institute during 7 Years
- Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells
- Contemporary retrotransposition of a novel non-coding gene induces exon-skipping in dystrophin mRNA
- Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center
- Insertion of the IL1RAPL1 gene into the duplication junction of the dystrophin gene
- Valproic acid increases SMN2 expression and modulates SF2/ASF and hnRNPA1 expression in SMA fibroblast cell lines