EFFECT OF FOOD RESTRICTION ON HEPATOTOXICITY OF CARBON TETRACHLORIDE IN RATS
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概要
- 論文の詳細を見る
Five-week-old Sprague-Dawley rats of both sexes were assigned to two types of feeding condition. One was fed ad libitum(AL)on commercial chow and another was fed a restricted amount of the chow(FR), approximately 75% of that fed in the AL condition. In each feeding condition, animals were orally administered carbon tetrachloride (CCl_4) at levels of 0(control), 0.1 or 0.2 ml / kg 6 days a week for 8 weeks. Lesions of the liver(hepatic cellular degeneration and fibrosis)and of the kidney(proximal tubular vacuolation and glomerular sclerosis)induced by CCl_4 were aggravated in the FR group. The FR-control showed a higher metabolic activity of aniline in the liver than the AL-control group. Plasma lipid-peroxide(LPO)level was higher in the AL-control group than in the FR-control group. With CCl_4 0.2 ml / kg treatment however, the plasma LPO level was reversed between the AL and the FR groups. Taking together these somewhat unexpected results, it was concluded that(1)25%food restriction increases toxicity of repeatedly administered CCl_4 in rats, and(2)aggravation of CCl_4 toxicity may be partly due to enhanced metabolic activation of CCl_4 resulting from food restriction.
- 日本トキシコロジー学会の論文
- 2000-02-28
著者
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Imai Kiyoshi
Hatano Research Institute Food And Drug Safety Center Laboratories Of Toxicology And Pathology
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Seki M
Department Of Anatomy Hyogo College Of Medicine
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IMAI Kiyoshi
Laboratory of Animal Reproduction, Department of Animal Science and Resources, College of Bioresourc
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Kasama Kikuko
Laboratory Of Toxicology Laboratory Of Biological Chemistry And Laboratory Of Pathology Hatano Resea
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Imai Kiyoshi
Dept. Of Toxicology And Pathology Hatano Research Institute Food And Drug Safety Center
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SEKI Makoto
Laboratory of Toxicology, Laboratory of Biological Chemistry and Laboratory of Pathology, Hatano Res
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Imai Kyoshi
Hatano Research Institute Food And Drug Safety Center
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Imai Kiyoshi
>Laboratory of Toxicology, Laboratory of Biological Chemistry and Laboratory of Pathology, Hatano Research Institute, Food and Drug Safety Center
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