"S2-1 STRATEGIC PROPOSALS FOR PREDICTING DRUG-DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : BASED ON SIXTEEN DEATHS CAUSED BY INTERACTIONS OF THE NEW ANTIVIRAL SORIVUDINE WITH 5-FLUOROURACIL PRODRUGS (<SYMPOSIUM 2>Strategy how we can learn drug-drug int
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概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1996-12-20
著者
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Watabe Tadashi
Department Of Drug Metabolism And Molecular Toxicology Tokyo University Of Pharmacy And Life Science
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Watabe T
Department Of Drug Metabolism And Molecular Toxicology School Of Phamacy Tokyo University Of Pharmac
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Watabe Tadashi
Department Of Drug Metabolism And Molecular Toxicology School Of Pharmacy Tokyo University Of Pharma
関連論文
- Metabolism-dependent inhibition of CYP3A4 and CYP2D6 by extracts from 26 herbal medicines
- Inhibition of human liver microsomal CYP3A4 and CYP2D6 by extracts from 78 herbal medicines
- Mechanism-Based Inactivation of Human Liver Microsomal CYP3A4 by Rutaecarpine and Limonin from Evodia Fruit Extract
- Sulfation of Environmental Estrogens by Cytosolic Human Sulfotransferases
- Formation of diconjugates from the phytoestrogen, genistein, in human liver.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- A Novel Guinea Pig Liver Glutathione S-Transferase Cross-reacting with Antibodies to Both Rat Mu- and Theta-Class Glutathione S- Transferases (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Rat and Mouse Liver Class Theta Glutathione S-Transferases Inactivating Reactive Metabolites Arylmethyl Sulfates (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Characterization of The a Gene Encoding Rat Class Theta Glutathione S-Transferase Yrs
- Novel Theta Class Glutathione S-Transferases Yrs-Yrs, Yrs-Yrs' and Yrs'-Yrs' Inactivating Reactive Sulfate Esters as Metabolites of Carcinogenic Arylmethanols (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- RAT LIVER GLUTATHIONE S-TRANSFERASE Yrs-Yrs INACTIVATING REACTIVE SULFATE ESTERS AS METABOLITES OF CARCINOGENIC ARYLMETHANOLS
- Metabolic Activation of Carcinogenic Arylmethanols by Sulfation : Microheterogeneity and Expression of Sulfotransferases (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- NOVEL TYPE OF GLUTATHIONE S-TRANSFERASES (θCLASS) IN RAT LIVER CYTOSOL
- Metabolic Activation and Inactivation of Carcinogenic Arylmethanols : Rat Liver Cytosolic Sulfotransferases and Glutathione S-Transferases (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- METABOLIC ACTIVATION OF CARCINOGENIC METHYL-SUBSTITUTED POLYNUCLEAR AROMATIC HYDROCARBONS BY HEPATIC P-450/SULFOTRANSFERASE : 7-METHYL- AND 7,12-DIMETHYLBENZ [α] ANTHRACENES AND 5-METHYL-CHRYSENE
- "B-6 Accumulation of the toxic cholesterol 7-hydroperoxides in rat skin by aging and a glutathione-dependent reduction of the hydroperoxides.
- RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
- Cytochrome P450 2D6 (CYP2D6) Inhibitory Constituents of Catharanthus roseus(Pharmacognosy)
- Mechanism-Based Inhibition of CYP3A4 by Constituents of Zingiber aromaticum(Pharmacognosy)
- 2C-21 Enzyme and Immunochemical Properties of Rat Liver Theta-Class Glutathione S-Transferases Yrs-Yrs and 5-5
- A novel mouse liver glutathione S-transferase Μ4 inactivating arylmethyl sulfates as carcinogenic reactive metabolites
- Effects of Pretreatment of Hep G2 Cells with β-Naphthoflavone on Cytotoxicity of Propranolol and its Active Metabolite 4-Hydroxypropranolol
- 7-Ethenyloxycoumarin as a New Substrate for Fluorophotometric Assay of Hepatic Microsomal Epoxidizing Activities
- 2C-20 Lethal Drug Interactions between Sorivudine and 5-Fluorouracil Caused by Suicidal Inactivation of Human Dihydropyrimidine Dehydrogenase by 5-(2-Bromovinyl) uracil
- Toxicokinetic and Enzymatic Studies on the Lethal Interactions between the Antiviral Sorivudine and the Anticancer Prodrugs of 5-Fluorouracil
- Dog and monkey liver cytosolic phenol sulfotransferases : bacterial expression and characterization.
- Role of chloride anion in activation of mutagenic arylmethyl sulfates.
- Analysis of DNA Adducts Formed from Carcinogenic Hydroxymethylarenes by Sulfoconjugation in Rat Liver (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- SULFOTRANSFERASE-MEDIATED FORMATION OF DNA ADDUCTS WITH CARCINOGENIC ARYLMETHANOLS IN RAT LIVER
- METABOLIC ACTIVATION OF CARCINOGENIC ARYLMETHANOLS BY MICROHETEROGENEOUS RAT LIVER SULFOTRANSFERASES
- Hydroxysteroid Sulfotransferase-mediated DNA Modification with Carcinogenic Polycyclic Hydroxymethylarenes (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- THIOL S-SULFATES, A NEW TYPE OF ACTIVE METABOLITES
- O-46 Sulfation of Endocrine-Disrupting Chemicals by Human Sulfotransferases.(Proceedings of the 27th Annual Meeting)
- 21C-01-5 Mechanism-based Inactivation of Human Dihydropyrimidine Dehydrogenase by 5-(2-Bromovinyl)uracil.
- Heterogeneity of Rat Liver Cytosolic Hydroxysteroid Sulfotransferase Activating Carcinogens
- "S2-1 STRATEGIC PROPOSALS FOR PREDICTING DRUG-DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : BASED ON SIXTEEN DEATHS CAUSED BY INTERACTIONS OF THE NEW ANTIVIRAL SORIVUDINE WITH 5-FLUOROURACIL PRODRUGS (Strategy how we can learn drug-drug int
- Regioselective Monosulfation and Disulfation of the Phytoestrogens Daidzein and Genistein by Human Liver Sulfotransferases
- Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT
- Simultaneous PET/MR body imaging in rats : initial experiences with an integrated PET/MRI scanner
- Metabolism-dependent inhibition of CYP3A4 and CYP2D6 by extracts from 26 herbal medicines