EFFECT OF ESTROGEN ON LIVER PLASMA MEMBRANE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of estrogen on plasma membrane was investigated using the primary cultured rat hepatocytes treated with carbon tetrachloride (CCl_4) and the isolated plasma membrane of rat liver. 17 β-Estradiol (E_2), at concentrations of 10^<-10>M to 10^<-4>M, 10^<-8>M to 10^<-6>M and 10^<-12>M to 10^<-4>M, had an inhibitory effect on the CCl_4-induced leakage of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, respectively from primary cultured rat hepatocytes. Diethylstilbestrol, which caused inhibition at a dose of 10^<-4>, did not inhibit any enzyme leakage ;at any further concentrations of 10^<-12>M to 10^<-6>M. In the isolated plasma membrane of rat liver, Mg^<2+>- and Na^+ , K^+- adenosine triphosphatase activity was increased by E_2 treatment at concentrations of 10^<-6>M and 10^<-4>M.
- 日本トキシコロジー学会の論文
- 1992-11-25
著者
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Miyamoto Hajime
Department Of Biopharmaceutics School Of Pharmaceutical Sciences Osaka University
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Miyamoto Masaki
Freclinical Safety Ciba-geigy Japan Ltd.
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NAGAE Yusuke
Drug Safety Laboratory, CIBA-GEIGY (JAPAN) Ltd.
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MIYAMOTO Masaki
Drug Safety Laboratory, CIBA-GEIGY (JAPAN) Ltd.
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Miyamoto H
Chemical Analysis Lab. Osaka Jpn
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Miyamoto Hajime
Department Of Anatomy Kyoto University Faculty Of Medicine
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Nagae Y
Toxicology
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MIYAMOTO Hajime
Department of Animal Science, Faculty of Agriculture, Kyoto University
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