Prolactin secretion in response to prolactin-releasing peptide and the expression of the prolactin-releasing peptide gene in the medulla oblongata are estrogen dependent in rats
スポンサーリンク
概要
- 論文の詳細を見る
Prolactin-releasing peptide (PrRP), recently isolated from bovine hypothalamus as an endogenous ligand to a seven transmembrane-domain orphan receptor, is a candidate specific prolactin-releasing factor. The prolactin-releasing activity of the peptide and the expression of the PrRP gene were examined in vivo in relation to estrogen status. Plasma prolactin levels increased significantly with a peak at 5 min after the administration of 50μg/kg PrRP in female rats in estrus under urethane anesthesia as compared with those in vehicle-treated control rats, but not in female rats in diestrus or proestrus or in male rats. In ovariectomized rats treated with supraphysiological concentration of estrogen, a dose-dependent increase of prolactin secretion in response to 2-50μg/kg PrRP was observed. However, the peak values induced by 50μg/kg PrRP were much less than those induced by 2μg/kg thyrotropin-releasing hormone (TRH). PrRP mRNA levels in the medulla oblongata were decreased by ovariectomy and increased by estrogen treatment. The data indicate that estrogen is prerequisite to the stimulatory effect of PrRP on the secretion of prolactin and to the increase of PrRP mRNA levels in the medulla oblongata. The weak in vivo potency of PrRP on prolactin secretion relative to TRH suggests that PrRP differs from the classical hypophysiotropic hypothalamic releasing hormones. [○!C]1999 Elsevier Science lreland Ltd. All rights reserved.
- 日本医科大学の論文
- 2000-03-25
著者
-
NAKATA Tomoko
Department of molecular Biology, Institute of Gerontology, Nippon Medical School
-
Katsumata Harumi
Department of Bioregulation, Institute of Gerontology, Nippon Medical School
-
Imaki Junko
Department of Anatomy, Nippon Medical School
-
Minami Shiro
Department of Bioregulation, Institute of Gerontology, Nippon Medical School
-
Imaki Junko
Department Of Anatomy Nippon Medical School
-
ONODERA Hidetaka
Department of Anesthesiology, Nippon Medical School
-
Tokita Reiko
Department of Bioregulation, Institute of Gerontology, Nippon Medical School
-
Konishi Shunichiro
Department of Bioregulation, Institute of Gerontology, Nippon Medical School
-
Nakata Tomoko
Department Of Bioregulation Institute Of Development And Aging Sciences Nippon Medical School
-
Tokita Reiko
Department Of Bioregulation Institute Of Development And Aging Sciences Nippon Medical School
-
Minami Shiro
Department Of Bioregulation Institute Of Development And Aging Sciences Nippon Medical School
-
Onodera Hidetaka
Department Of Anatomy Nippon Medical School
-
Konishi Shunichiro
Department Of Bioregulation Institute Of Gerontology Nippon Medical School
-
Katsumata Harumi
Department Of Bioregulation Institute Of Gerontology Nippon Medical School
関連論文
- Correlation of Allelic Losses and Clinicopathological Factors in Primary Breast Cancers
- Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan
- Multiplex Mutation Screening of the BRCA1 Gene in 1000 Japanese Breast Cancers
- Expression of Corticotropin-Releasing Hormone Type 1 Receptor in Paraventricular Nucleus after Acute Stress
- Developmental expression of mafB messenger ribonucleic acids in rat skin by in situ hybridization histochemistry
- Prolactin secretion in response to prolactin-releasing peptide and the expression of the prolactin-releasing peptide gene in the medulla oblongata are estrogen dependent in rats
- Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma
- Fusion of a Novel Gene, ELKS, to RET Due to Translocation t(10;12)(q11;p13) in a Papillary Thyroid Carcinoma
- A novel LDLR mutation, H190Y, in a Utah kindred with familial Hypercholesterolemia
- Noninvasive positive pressure ventilation in patients with perioperative negative pressure pulmonary edema
- Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene
- Binding Affinity of Bunazosin, Dorzolamide, and Timolol to Synthetic Melanin
- Human Growth Hormone Induces SOCS3 and CIS mRNA Increase in the Hypothalamic Neurons Hypophysectomized Rats
- Regulation of Corticotropin-Releasing Factor (CRF) Type-1 Receptor Gene Expression by CRF in the Hypothalamus
- Schizophrenia and narcolepsy : A review with a case report
- Treatment of an Unruptured Fusiform Aneurysm of the Internal Carotid Artery Associated With Wegener's Granulomatosis by Endovascular Balloon Occlusion : Case Report
- Familial Hypercholesterolemia Kindred in Utah with Novel C54S Mutations of the LDL Receptor Gene.
- Familial Hypercholesterolemia in Utah Kindred with Novel R103W Mutations in Exon 4 of the LDL Receptor Gene.
- Familial Hypercholesterolemia in Utah Kindred with Novel 2412-6 Ins G Mutations in Exon 17 of the LDL Receptor Gene.