アルファロール散と他の散剤・顆粒剤との配合変化試験

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The compatibility test was conducted between alfacalcidol powder (Alfarol^<[O!R]> powder) and other drugs which were frequent, used with alfacalcidol powder as combination drugs at dispensing, such as lactose (LA), precipitated calcium carbonate powder (CO), calcium lactate powder (CL), Calcicol^<[O!R]> powder (CG), Ulcerlmin^<[O!R]> fine granule (UL), Marzulene-S^<[O!R]> granule (MS), magnesium oxide fine granule (MO), Tagamet^<[O!R]> fine granule (TA). Gaster powder (GA), Kolantyl granule (KO), Acenalin fine granule (AS), Ternelin^<[O!R]> granule (TN), Rize granule (RZ), Loxionin^<[O!R]> fine granule (LO), Solantal^<[O!R]> fine granule (SO), Alnert^<[O!R]> granule (AL), and Panaldine^<[O!R]> fine granule (PA). Combination drugs were stored at 5℃ and 25℃ with 75% RH. A change in the drug appearance was observed just after, and 2, 4, and 8 weeks after dispensing. In addition, the contents of alfacalcidol were also determined using high-performance liquid chromatography at the same time points. In the assessment of change in appearance, TN and LO turned to yellow 4 and 8 weeks after dispensing under the conditions at 25℃ with 75% RH, respectively, however, no change was observed in the appearance in other combinations under the above two conditions. The residual rate of the alfacalcidol content declined by about to 90% or was lower at 8 weeks after dispensing in combination with GA when stored at 5℃. Under the conditions at 25℃ with 75% RH, the residual rates declined by about to 90% or lower at 2 weeks after dispensing in combination with CO, UL, TA, GA, RZ, 4 weeks after dispensing in combination with KO, LO, and SO, and 8 weeks after dispensing in combination with MO and AS. The residual rates remained 90% or higher even 8 weeks after dispensing in combination with LA, CL, CG, MS, AL, and PA.
日本医療薬学会の論文
1998-12-10

アルファロール散と他の散剤・顆粒剤との配合変化試験

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