Sorption of Isosorbide Dinitrate from Solution to Ethylenc-Vinylacetate Copolymer Membrane : Permeation of Isosorbide Dinitrate through Ethylene-Vinylacetate Copolymer Membrane

概要

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In ascertain the mechanism of the sorption of isosorbide dinitrate (ISDN) from the solution to the ethylene-vinylacetate copolymer (EVA) membrane, we investigated the permeation of ISDN through an EVA membrane. using a membrane permeation apparatus. The partition coefficient between the EVA membrane and water was constant around 6.3 and was not affected by temperature. It was observed that the permeation-time curve of ISDN through the EVA membrane was straight from the 4 to 7-day period, and that the amount of ISDN permeated was proportional to the time. The permeation of ISDN through the EVA membrane could be analyzed by means of a distribution-diffusion model, which provided us with a method for precisely calculating Pi, a membrane permeation coefficient. Pi depends on temperature, such that as temperature rises, it increases. For example, it increased from 7.37×10^<-5> (cm^<2> . h^<-1>) at 25℃ to 1.73×10^<-4> (cm^<2>・h^<-1>) at 35℃.
日本医療薬学会の論文
1996-06-10