Effect of pH on the Sorption of In-solution Diazepam into the Ethylene-Vinylacetate Copolymer Membrane

概要

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We investigated the mechanism for diazepam sorptions into the ethylene-vinylacetate (EVA) copolymer membrane. A linear relationship was found between the amount of diazepam sorbed into the EVA membrane and the diazepam concentration when it was 5-20 μg/ml. The sorbed amount was influenced by pH. When the diazepam concentration in solution was 20 μg/ml, it was 0.17 mg/g at pH 3.2 and increased to 0.74 mg/g at pH 7.0. Moreover, the experimental data showed a similar tendency as the calculated values, suggesting that the amount of diazepam sorbed was proportional to the concentration of the diazepam molecular form.
日本医療薬学会の論文
1994-10-20