HPLCによる軟膏中メシル酸ガベキサートの安定性の検討

概要

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The stability of gabexate mesilate in ointments prepared with macrogol ointment or with white petrolatum was examined by the use of high-performance liquid chromatography (HPLC). The experimental conditions of HPLC were as follows; column: Waters Radial-PAK C^18, mobile phase: methanol: water=75:25 (v:v) added triethanolamine and phosphoric acid in final concentration of 1.0% (w/v), 0.067% (w/v) respectively. detection: at 236nm. The decomposition of gabexate mesilate in macrogol ointment seemed to obey an apparent first order kinetics. This decomposition rate was promoted by the addition of zinc oxide owing to the change of pH to alkaline region. Gabexate mesilate in macrogol ointment was most stable around pH 4. Gabexate mesilate was stable in white petrolatum, and its stability was decreased by the presence of water or zinc oxide. But the effect of zinc oxide was decreased in the absence of water in the medium.
日本医療薬学会の論文
1989-08-20