20%塩化リゾチーム細粒剤の製剤評価 : (2) 溶解時の安定性と配合性の検討

概要

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Stability and compatibility of water-soluble 20% lysozyme chloride fine granules used as oral liquid preparation were compared with those of a currently used syrup preparation. In the test for change on mixing performed in reference to the method of Kojiro et al., change with time in appearance, odor, pH, and lysozyme activity (by a bacteriolysis method) was examined. Stability test for an aqueous solution demonstrated that this preparation is unstable in alkaline solutions but stable in acidic solutions, proving its usefulness as an oral liquid preparation. Compatibility test showed that the preparation is not compatible, among the 21 kinds of respiratory, antiallergic and antibiotic drugs tested, with Bisolvon Syr., Conc. Brocin-Codeine Syr., Senega Syr., Atarax P Syr. and Cefro D. S. When the stability and compatibility of the preparation were compared with those of lysozyme chloride syrup, no apparent difference was observed.
日本医療薬学会の論文
1984-08-20