血中薬物濃度測定値への溶血, 乳びおよび黄疸因子の影響

概要

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In the measurement of a concentration of drug in serum by a method based on the enzyme antibody principle, the effects of serum factors such as hemolysis, chyle and icterus on the measured values were studied. Phenobarbital(PB), phenytoin (PHT), carbamazepine (CBZ), valproic acid (VPA) and digoxin (DGX) levels in serum were measured by the enzyme multiplied immunoassay technique (EMIT), and PB, PHT and CBZ levels by the substrate labeled fluorescence immunoassay (SLFIA). The effects somewhat varied by serum factors such as hemolysis, chyle and icterus, testing methods and drug; but as far as those 3 factors remain on the levels ordinarily observed, such effects on the measured values may be almost negligible. However, the DGX level rose more than 10% under the influence of bilirubin (5 mg/dl).
日本医療薬学会の論文
1984-06-20