注射用ラタモキセフナトリウムの安定性に関する基礎的研究

概要

論文の詳細を見る
The stability of sodium latamoxef (Shiomarin; LMOX) in aqueous solution, a newly developed oxacephem antibiotic for injection, was tested at 5°, room temperature (20 ± 5°), and 37°. Decomposition products were studied with thin-layer chromatography, bioautography and spectrophotometry. Furthermore, the residual potency was determined by a microbiological assay (cylinder-plate method). The results were as follows: 1) LMOX (1g (potently)/10ml) aqueous solution showed changes in color, without any variation in pH after 7 days. Its residual potency after 7 days was 95.1%・ The residual potencies after 24 hours were 99.0% at 5° with increased color intensity, 96.5% at 20° and 82.6% at 370. 2) Aqueous solution of LMOX showed no color change at pH 3.60, but developed a light brown color at pH 8.00 and a light blue color at pH 10.00. No decrease in potency was observed after 24 hours at pH 3.60-10.10 at 5° or pH 3.60-9.00 at 20° and after 6 hours at pH 3.60-10.00 at 37°.
日本医療薬学会の論文
1983-12-20